4-MMC MEPHEDRONE | 4-MMC Mephedrone-Powder 500g

4-MMC (Mephedrone) is a synthetic entactogenic stimulant of the substituted cathinone class.

4-MMC
(Mephedrone) is known for producing a mixture of classic stimulant and
entactogenic effects effects reminiscent of cocaine and MDMA.

It
comes in the form of tablets or a powder, which users can swallow,
snort, inject or insert rectally, producing effects which are somewhat
similar to those of MDMA, amphetamine, and cocaine.

Pharmacology

Given
its chemical structure, mephedrone is likely to act as a releasing
agent and a reuptake inhibitor for monoamine neurotransmitters such as
dopamine, serotonin and noradrenaline.

Several articles published
near the end of 2011 examined the effects of mephedrone in the brains
of rats, as well as examining the reinforcing potential of mephedrone.
Dopamine and serotonin were collected using microdialysis, and increases
in dopamine and serotonin were measured. Mephedrone administration
caused about a 500% increase in dopamine, and about a 950% increase in
serotonin. They reached their peak concentrations at 40 minutes and 20
minutes and returned to baseline by 120 minutes after injection.

Analysis
of the ratio for dopamine and serotonin indicated mephedrone was
preferentially a serotonin releaser, with a ratio of 1.22:1 (serotonin
vs. dopamine). Additionally, half-lives for the decrease in dopamine and
serotonin were calculated and found to have decay rates of 24.5 minutes
and 25.5 minutes.

Tolerance and addiction potential

As
with other stimulants, the chronic use of mephedrone can be considered
moderately addictive with a high potential for abuse and is capable of
causing psychological dependence among certain users. When addiction has
developed, cravings and withdrawal effects may occur if a person
suddenly stops their usage.

Tolerance to many of the effects of
mephedrone develops with prolonged and repeated use. This results in
users having to administer increasingly large doses to achieve the same
effects. After that, it takes about 3 – 7 days for the tolerance to be
reduced to half and 1 – 2 weeks to be back at baseline (in the absence
of further consumption). Mephedrone presents cross-tolerance with all
dopaminergic stimulants, meaning that after the consumption of
mephedrone all stimulants will have a reduced effect.

Side effects

The
effects listed below are based upon the subjective effects index and
personal experiences of PsychonautWiki contributors. The listed effects
should be taken with a grain of salt and will rarely (if ever) occur all
at once, but heavier doses will increase the chances and are more
likely to induce a full range of effects. Likewise, adverse effects
become much more likely on higher doses and may include serious injury
or death.

Uses

Users have reported that
mephedrone causes euphoria, stimulation, an enhanced appreciation for
music, an elevated mood, decreased hostility, improved mental function
and mild sexual stimulation; these effects are similar to the effects of
cocaine, amphetamines and MDMA, and last different amounts of time
depending on the way the drug is taken. Of 70 Dutch users of mephedrone,
58 described it as an overall pleasant experience and 12 described it
as an unpleasant experience.[10] In a survey of UK users who had
previously taken cocaine, most users found it produced a better-quality
and longer-lasting high and was less addictive. The users were also
asked to compare the “risk”, and they answered that it was equal.[1] A
study of users in Northern Ireland found they did not equate the fact
that mephedrone was legal with it being safe to use. This was contrary
to another study in New Zealand, where users of benzylpiperazine thought
that because it was legal, it was safe.